Mathematics delineates the contours of the objects of the world, cuts them from their background, structures them with strong and stable physico-mathematical meanings. This historical constitution of the meaning of the inert has limits with regard to the description of living processes; the informational alternative diverts the understanding of biology into a meaningless dissipation of the organism, a partially programmed bag of molecules. The search for the organicity of knowledge and of the object of knowledge is the challenge that confronts us, especially with regards to the new interactions we have with the ecosystem. What interface between disciplines can contribute to this research program for a meaningful unity yet to be constructed, with the world?